99 research outputs found
Bounds on \"{U}bercrossing and Petal Numbers for Knots
An -crossing is a point in the projection of a knot where strands
cross so that each strand bisects the crossing. An \"ubercrossing projection
has a single -crossing and a petal projection has a single -crossing such
that there are no loops nested within others. The \"ubercrossing number,
, is the smallest for which we can represent a knot with
a single -crossing. The petal number is the number of loops in the minimal
petal projection. In this paper, we relate the \"{u}bercrossing number and
petal number to well-known invariants such as crossing number, bridge number,
and unknotting number. We find that the bounds we have constructed are tight
for -torus knots. We also explore the behavior of \"{u}bercrossing
number under composition.Comment: 13 pages, 8 figure
Recurrent transcriptional responses in AML and MDS patients treated with decitabine
The molecular events responsible for decitabine responses in myelodysplastic syndrome and acute myeloid leukemia patients are poorly understood. Decitabine has a short serum half-life and limited stability in tissue culture. Therefore, theoretical pharmacologic differences may exist between patient molecular changes in vitro and the consequences of in vivo treatment. To systematically identify the global genomic and transcriptomic alterations induced by decitabine in vivo, we evaluated primary bone marrow samples that were collected during patient treatment and applied whole-genome bisulfite sequencing, RNA-sequencing, and single-cell RNA sequencing. Decitabine induced global, reversible hypomethylation after 10 days of therapy in all patients, which was associated with induction of interferon-induced pathways, the expression of endogenous retroviral elements, and inhibition of erythroid-related transcripts, recapitulating many effects seen previously in in vitro studies. However, at relapse after decitabine treatment, interferon-induced transcripts remained elevated relative to day 0, but erythroid-related transcripts now were more highly expressed than at day 0. Clinical responses were not correlated with epigenetic or transcriptional signatures, although sample size and interpatient variance restricted the statistical power required for capturing smaller effects. Collectively, these data define global hypomethylation by decitabine and find that erythroid-related pathways may be relevant because they are inhibited by therapy and reverse at relapse
AGI for Agriculture
Artificial General Intelligence (AGI) is poised to revolutionize a variety of
sectors, including healthcare, finance, transportation, and education. Within
healthcare, AGI is being utilized to analyze clinical medical notes, recognize
patterns in patient data, and aid in patient management. Agriculture is another
critical sector that impacts the lives of individuals worldwide. It serves as a
foundation for providing food, fiber, and fuel, yet faces several challenges,
such as climate change, soil degradation, water scarcity, and food security.
AGI has the potential to tackle these issues by enhancing crop yields, reducing
waste, and promoting sustainable farming practices. It can also help farmers
make informed decisions by leveraging real-time data, leading to more efficient
and effective farm management. This paper delves into the potential future
applications of AGI in agriculture, such as agriculture image processing,
natural language processing (NLP), robotics, knowledge graphs, and
infrastructure, and their impact on precision livestock and precision crops. By
leveraging the power of AGI, these emerging technologies can provide farmers
with actionable insights, allowing for optimized decision-making and increased
productivity. The transformative potential of AGI in agriculture is vast, and
this paper aims to highlight its potential to revolutionize the industry
Benchmarking of the Dose Planning Method (DPM) Monte Carlo code using electron beams from a racetrack microtron
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135135/1/mp1512.pd
Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma
The pluripotency transcription factor SOX2 is essential for the maintenance of glioblastoma stem cells (GSC), which are thought to underlie tumor growth, treatment resistance, and recurrence. To understand how SOX2 is regulated in GSCs, we utilized a proteomic approach and identified the E3 ubiquitin ligase TRIM26 as a direct SOX2-interacting protein. Unexpectedly, we found TRIM26 depletion decreased SOX2 protein levels and increased SOX2 polyubiquitination in patient-derived GSCs, suggesting TRIM26 promotes SOX2 protein stability. Accordingly, TRIM26 knockdown disrupted the SOX2 gene network and inhibited both self-renewal capacity as well as in vivo tumorigenicity in multiple GSC lines. Mechanistically, we found TRIM26, via its C-terminal PRYSPRY domain, but independent of its RING domain, stabilizes SOX2 protein by directly inhibiting the interaction of SOX2 with WWP2, which we identify as a bona fide SOX2 E3 ligase in GSCs. Our work identifies E3 ligase competition as a critical mechanism of SOX2 regulation, with functional consequences for GSC identity and maintenance
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
On the Diversity of Phyllodocida (Annelida: Errantia), with a Focus on Glyceridae, Goniadidae, Nephtyidae, Polynoidae, Sphaerodoridae, Syllidae, and the Holoplanktonic Families
Este artículo contiene 65 páginas, 26 figuras, 1 tabla.Phyllodocida is a clade of errantiate annelids characterized by having ventral sensory palps, anterior enlarged cirri, axial muscular proboscis, compound chaetae (if present) with a single ligament, and of lacking dorsolateral folds. Members of most families date back to the Carboniferous, although the earliest fossil was dated from the Devonian. Phyllodocida holds 27 well-established and morphologically homogenous clades ranked as families, gathering more than 4600 currently accepted nominal species. Among them, Syllidae and Polynoidae are the most specious polychaete groups. Species of Phyllodocida are mainly found in the marine benthos, although a few inhabit freshwater, terrestrial and planktonic environments, and occur from intertidal to deep waters in all oceans. In this review, we (1) explore the current knowledge on species diversity trends (based on traditional species concept and molecular data), phylogeny, ecology, and geographic distribution for the whole group, (2) try to identify the main knowledge gaps, and (3) focus on selected families: Alciopidae, Goniadidae, Glyceridae, Iospilidae, Lopadorrhynchidae, Polynoidae, Pontodoridae, Nephtyidae, Sphaerodoridae, Syllidae, Tomopteridae, Typhloscolecidae, and Yndolaciidae. The highest species richness is concentrated in European, North American, and Australian continental shelves (reflecting a strong sampling bias). While most data come from shallow coastal and surface environments most world oceans are clearly under-studied. The overall trends indicate that new descriptions are constantly added through time and that less than 10% of the known species have molecular barcode information availableWe acknowledge support of the publication fees by the CSIC Open Access Publication
Support Initiative through its Unit of Information Resources for Research (URICI) and the Open
Access Publication Funds of the Georg-August-Universität Göttingen. This research was funded
by the Spanish “Agencia Estatal de Investigación” (AEI) and the European Funds for Regional
Development (FEDER), Research Project PopCOmics (CTM2017-88080) to DM; the Russian Scientific
Foundation for Basic Research, grant no. RFBR 18-05-00459 to TAB; Fundação para a Ciência e
a Tecnologia (FCT), contract foreseen in the Decree-Law 57/2016 (Nrs 4-6, art. 23), changed by
Law 57/2017 to AR and FCT/MCTES to CESAM (UIDP/50017/2020+UIDB/50017/2020) through
national funds; São Paulo Research Foundation (FAPESP), fellowship proc. 2007/53040-9 to MVF;
Spanish MINECO, AEI, Comunidad Autónoma de las Islas Baleares, European Social Funds and
Ramón y Cajal program, RYC-2016-20799 to MC; FCT and ESF (SFRH/BD/131527/2017) through a
PhD grant to MALT.Peer reviewe
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